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当前学科：皮肤与性病学综合练习
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一个62岁男性，自幼就有弥漫性掌跖高度角化增厚，身上其他部位无皮损，从未接受过治疗。根据这一病史，最可能的病因和相关因素是什么（）
A . 由于反复创伤导致获得性角化过度
B . 内脏恶性肿瘤
C . 遗传因素
D . 外界因素
E . 药物所致
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